Tag: Refractory gerd

According to studies, up to one-third of patients with suspected GERD do not respond symptomatically to proton pump inhibitors (PPIs) like Nexium. The ineffectiveness of a medication that is considered a gold standard for managing acid reflux can be frustrating, pointing to deeper issues beyond simple acid suppression.

For some patients, traditional treatments like proton pump inhibitors (PPIs) fail to fully alleviate symptoms of gastroesophageal reflux disease (GERD), with studies showing a significant portion of patients have refractory symptoms. This raises the question: **does amitriptyline help with GERD?** For certain patients with persistent pain or esophageal hypersensitivity, the answer is yes, though it is used differently than standard acid suppressants.