Tag: Refractory shock

Approximately 50% of patients with septic shock eventually develop a state of vasopressor-refractory vasodilatory shock, necessitating alternative therapies to restore hemodynamic stability. For intensive care clinicians managing these challenging cases, knowing which of the following drugs would be used to treat vasodilatory shock in patients no longer responding to high doses of conventional vasopressors is crucial.

Sepsis is a medical emergency with US mortality rates remaining between 20% and 36%, driving the need for rapid escalation of care. When initial broad-spectrum antibiotics and fluid resuscitation fail to stabilize a patient's hemodynamics, clinicians must implement **what is the second-line of treatment for sepsis?** This involves a critical, time-sensitive shift in pharmacological and supportive strategies to counteract worsening organ dysfunction.