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Tag: Rem sleep suppression

Explore our medication guides and pharmacology articles within this category.

Can Amitriptyline Cause Sleep Issues? Separating Sedation from Disruption

3 min read
Despite its common off-label use as a sedative for insomnia, a significant percentage of people experience paradoxical or disruptive sleep issues with amitriptyline. While it often makes individuals feel sleepy and helps with initial sleep onset, the medication profoundly alters the fundamental architecture of sleep, affecting both quality and daytime function.