How do ACE inhibitors cause renal vasoconstriction? Exploring a paradoxical renal effect
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4 min read
While ACE inhibitors are primarily known for causing vasodilation, a critical exception occurs in patients with pre-existing renal disease, particularly bilateral renal artery stenosis. In these high-risk scenarios, blocking the body's compensatory vasoconstrictor mechanisms can lead to a paradoxical decline in kidney function, often described as functional renal vasoconstriction.