Why is Nitrofurantoin not Used in Pyelonephritis?
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3 min read
According to infectious disease guidelines, nitrofurantoin is explicitly contraindicated for the treatment of pyelonephritis, a severe kidney infection. This is primarily due to its pharmacokinetic profile—its inability to achieve therapeutic concentrations within the kidney's tissue—which is the main reason why nitrofurantoin is not used in pyelonephritis.
