What is the California cocktail for depression?
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4 min read
Initially publicized as an effective regimen for treatment-resistant depression, the combination of venlafaxine and mirtazapine was popularly dubbed the "California cocktail" or "California rocket fuel". However, the use of this potent combination remains controversial, with subsequent large-scale studies providing disappointing evidence of its superior efficacy. This treatment strategy, primarily for severe cases, requires careful consideration and monitoring by a healthcare professional.
