Are NSAIDs reversible or irreversible? Unpacking the pharmacology of common painkillers
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4 min read
While most nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are reversible inhibitors of the cyclooxygenase (COX) enzyme, a key outlier, aspirin, acts irreversibly and has a uniquely long-lasting effect, especially on platelets. Understanding whether NSAIDs are reversible or irreversible is critical for grasping their different clinical applications and safety profiles.
