Tag: Ribosomal modification

Macrolide resistance among *Streptococcus pneumoniae*, a major cause of community-acquired pneumonia, has escalated at alarming rates globally, with one U.S. study reporting a resistance rate of 39.5%. Understanding **what is the most common mechanism of macrolide resistance** is crucial for developing new treatment strategies and combating this persistent public health threat.

According to a comprehensive 2018 review, a clinically relevant mechanism for macrolide resistance in pathogenic bacteria is the methylation of ribosomal RNA. This is just one of several strategies bacteria employ to circumvent these crucial antibiotics, posing a significant challenge to public health.