Tag: Route of administration

As a rapid and predictable anticoagulant, bivalirudin's exclusive route of administration is intravenous (IV). This precise delivery method is essential for its use in critical cardiovascular procedures, such as percutaneous coronary intervention (PCI) and the management of heparin-induced thrombocytopenia (HIT).

The choice for the best route of administration for vancomycin is determined by the infection's location, with intravenous (IV) vancomycin reserved for systemic infections and oral vancomycin used exclusively for treating intestinal infections. This is due to the antibiotic's extremely poor oral bioavailability, with less than 10% of the drug being absorbed into the bloodstream from the gut. Therefore, the appropriate route is dictated by the specific therapeutic goal.

According to the Merck Manual, drugs administered via the otic route are applied as liquid drops into the outer ear canal to treat local infections or inflammation. This specialized delivery method, which clarifies what does "otic route" mean in a pharmaceutical context, ensures high local drug concentration while minimizing systemic effects.