Tag: Sams

Over 30% of people who try statins like atorvastatin experience some form of muscle pain [1.4.2]. For older adults, this raises a critical question: **Does atorvastatin affect polymyalgia rheumatica (PMR)?** The answer is complex, involving overlapping symptoms and the risk of misdiagnosis.

According to a major meta-analysis of over 4 million patients, the worldwide prevalence of statin intolerance is approximately 9.1% [1.2.1]. Answering the question of **how common is statin intolerance** requires looking at the difference between clinical trials and real-world data, where reported rates can be higher [1.2.3].

Statin intolerance is a significant clinical challenge, with some degree of intolerance reported in as many as 5% to 30% of patients [1.2.1, 1.2.2]. **What is statin intolerance?** It's characterized by adverse effects from statin therapy that improve or resolve upon reducing the dose or stopping the medication.

While statins are vital for managing cholesterol, muscle pain is a common side effect, with some studies showing it affects up to 27% of patients [1.2.1]. So, what does leg pain from statins feel like and when is it a cause for concern?

While statins are among the most effective medications for lowering cholesterol and preventing heart disease, a significant number of people report muscle-related side effects. For those who are physically active or seeking to become more so, this raises a crucial question: do statins reduce stamina, and if so, how can it be managed?

While statins are highly effective for lowering cholesterol, studies show that between 7% and 29% of patients report statin-associated muscle symptoms (SAMS) [1.2.1, 1.2.2]. The question of *what do statins do to leg muscles?* is a significant concern for many individuals on this therapy.

While the prevalence of statin-associated muscle symptoms (SAMS) varies, some observational studies report them in 7–29% of patients [1.2.1]. For those affected, a key question is: **where are statin muscle pains located** and how can they be identified?

While statins are highly effective for managing cholesterol, observational studies report that up to 30% of users experience muscle-related issues. These side effects, known as statin-associated muscle symptoms (SAMS), often target specific large muscle groups, leading many patients to question which muscles are most affected by statins.