Tag: Second line therapy

Metformin is one of the most widely used medications globally for treating type 2 diabetes, but its effectiveness often decreases over time. If you notice signs that your blood sugar is no longer controlled, it may mean that the initial treatment plan needs adjustment, signaling what happens when metformin doesn't work anymore.

For many patients whose epilepsy is not controlled by first-line medications, a shift to alternative treatments becomes necessary. This is when clinicians must consider what are the second line anti epileptic drugs to effectively manage the condition and prevent further seizures.

According to the ATLANTIS trial, a large-scale study published in *The Lancet*, low-dose amitriptyline is a safe and effective second-line treatment for managing irritable bowel syndrome (IBS) symptoms. This article delves into how this medication works on the gut-brain axis and answers the critical question, is amitriptyline good for IBS?