Tag: Seizure risk

According to a 2018 review in *PubMed*, specific antidepressants like bupropion and clomipramine are not recommended for patients with epilepsy due to an increased risk of seizures. This critical information answers the question, 'Which antidepressant is contraindicated in epilepsy?' and is essential for safe and effective treatment.

According to extensive research, nearly all first- and second-generation antipsychotic drugs have been implicated in increasing the risk of epileptic seizures by lowering the seizure threshold. This means for certain individuals, the question of "do antipsychotics increase seizure risk?" is a critical clinical consideration, with the actual risk varying significantly between different medications and patient-specific factors.

According to the official FDA prescribing information, Rexulti (brexpiprazole) should be used with caution in patients with a history of seizures or with other conditions that lower the seizure threshold. This confirms that, as with many other antipsychotic medications, **Rexulti** carries a risk of increasing a patient's susceptibility to seizures.

While initial clinical trials showed a low seizure incidence of 0.22% with Invega, manufacturers and medical sources explicitly state that it can lower the seizure threshold. This makes answering the question, **Does Invega lower seizure threshold?** a critical part of understanding the medication's safety profile.

According to a prospective study in pediatric patients with epilepsy, risperidone did not affect seizure frequency in 94.5% of cases. However, the product labeling advises caution for patients with a history of seizures, which raises the critical question: is risperidone safe in epilepsy?. This concern arises because some psychotropic medications can lower the seizure threshold.

Over 5% of all cases of status epilepticus—a dangerous, prolonged seizure—are caused by a drug or poison, highlighting the significant link between substances and seizure activity. This guide explores **what drugs can trigger epilepsy** and seizures, and the factors that increase a person's risk.

Amantadine may rarely precipitate or worsen seizure activity [1.2.1]. This medication, used for conditions like Parkinson's disease, requires close monitoring in patients with a history of epilepsy or a predisposition to seizures [1.2.1, 1.4.1].

Retrospective studies have investigated the relationship, with a 2012 chart review of 205 patients finding no major seizure exacerbation associated with modafinil use, even in those with existing epilepsy. Despite this, concerns remain, and a cautious approach is taken when prescribing modafinil to those with seizure disorders.

Case reports have documented serious neurotoxic effects, including gait disturbances and confusion, in elderly patients who took bupropion and amantadine together. Because of this, understanding the severe risks associated with taking bupropion and amantadine together is critically important before considering this combination.

According to reputable sources like Drugs.com, the coadministration of bupropion and tramadol carries a highly clinically significant drug interaction warning, with risks often outweighing the benefits. This information directly addresses a serious question for many patients: **Can I take wellbutrin and tramadol together?**