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Tag: Sequential nephron blockade

Explore our medication guides and pharmacology articles within this category.

What is combination diuretic therapy with thiazides?

4 min read
According to the CDC, approximately 6.2 million adults in the United States have heart failure, and managing fluid overload in these patients can become challenging. Combination diuretic therapy with thiazides is a key therapeutic strategy used when a single diuretic medication is no longer effective.

Understanding Sequential Blockade: Why Do We Give Thiazide Before Loop Diuretics?

6 min read
For some patients with refractory fluid overload, standard high doses of loop diuretics become ineffective over time, a phenomenon known as diuretic resistance. To overcome this therapeutic hurdle, clinicians often turn to a combination strategy that includes a thiazide diuretic, leveraging a powerful pharmacological principle called sequential nephron blockade. Administering the thiazide first is a calculated step to maximize the synergistic effect of these two drug classes.