Tag: Serotonin antagonists

Over 90% of the body's serotonin is produced in the gastrointestinal (GI) tract, where it plays a key role in digestion and other functions. Multiple types of medications act as a serotonin antagonist, blocking the action of serotonin at different receptor sites to produce a range of therapeutic effects.

Nausea and vomiting affect an estimated 30% of patients within 24 hours after surgery and millions of others annually due to various causes like motion sickness and chemotherapy. The key to understanding how does vomit stopping medicine work lies in a sophisticated communication system involving the brain and gut.

Despite being a common and effective antiemetic, ondansetron is strictly contraindicated in cases of bowel obstruction. Its pharmacological action, while beneficial for treating nausea from chemotherapy or surgery, poses significant risks when intestinal blockage is present by worsening the condition and delaying diagnosis.

While Zofran (ondansetron) is a highly effective antiemetic, it's not a universal solution for all types of nausea. Therefore, when a patient asks, "**what if Zofran doesn't work?**," it signals the need to investigate alternative pharmacological options, non-medication strategies, or a potential underlying cause for their symptoms.

In population studies, over 50% of adults reported at least one episode of nausea in the preceding year [1.9.1]. While effective, it's crucial to ask: what are the side effects of anti-nausea medication? This article explores them.