Tag: Sertraline and diphenhydramine

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Can you take Unisom with Zoloft? A Guide to Interactions and Safety

Oct 10, 2025 •

4 min read

Insomnia is a common side effect for those taking antidepressants like Zoloft [1.7.7]. This raises an important question for many: Can you take Unisom with Zoloft to get a better night's sleep? While possible, it carries notable risks.