Tag: Sirtuins

While the idea of a universal anti-aging pill remains science fiction, a 2024 interview with a prominent longevity researcher highlighted several FDA-approved drugs that have shown potential to reduce age-related mortality in humans. The broader scientific conversation often includes four highly-researched compounds: Rapamycin, Metformin, Nicotinamide Mononucleotide (NMN), and Resveratrol, raising the question: **What are the 4 drugs for longevity?**

While primarily a type 2 diabetes medication, a 2014 observational study showed that diabetic patients taking metformin had a lower mortality risk than non-diabetic controls. This intriguing finding helps explain **why does David Sinclair take metformin?** as part of his regimen for healthy aging.

Resveratrol has long been celebrated for its potential anti-aging and cardioprotective properties, yet its effectiveness is hampered by remarkably low oral bioavailability, with less than 20% being absorbed in its active form. For this reason, the quest for what's better than resveratrol has led researchers to investigate compounds with superior pharmacological profiles that can deliver more pronounced health benefits.

Studies consistently show that nicotinamide adenine dinucleotide (NAD+) levels decline with age in a wide range of species, from worms to humans. This has fueled widespread interest in the question: Can NAD reverse aging by replenishing these dwindling cellular stores?