Which antidepressant has the worst withdrawal symptoms?
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4 min read
According to meta-analyses, some studies suggest that over a quarter of people attempting to stop antidepressants experience withdrawal symptoms. When considering which antidepressant has the worst withdrawal symptoms, experts frequently point to those with a shorter half-life, like Paroxetine (Paxil) and Venlafaxine (Effexor), due to the more rapid drop in neurotransmitter levels.