Tag: Solubility

According to the Biopharmaceutics Classification System (BCS), the antiretroviral drug bictegravir is classified as a **BCS Class 2** molecule [1.2.1, 1.3.1]. This classification is defined by its low solubility and high permeability, which significantly influences its absorption and formulation.

Over 800,000 prescriptions for lidocaine were filled in the United States in 2023. Understanding **what is the difference between lidocaine and lidocaine hydrochloride** is crucial to appreciating why this medication is available in two distinct chemical forms for different medical purposes.

Over 30 different approved medicines incorporate cyclodextrins as a key excipient to improve drug properties. A cyclodextrin tablet leverages this unique sugar molecule to address several critical challenges in modern drug formulation, such as poor solubility and stability, thereby improving therapeutic outcomes.

According to the European Pharmacopoeia, over 200 active ingredients in medications are formulated as hydrochlorides, proving its vital role in modern medicine. When you see "HCl" after a drug's name, it signifies the formation of a hydrochloride salt, a crucial chemical modification that profoundly impacts how the medication works in your body. This common pharmaceutical practice is used to make drugs more effective, safer, and easier to manufacture.

Over 15% of all clinically used medications are formulated as hydrochloride salts. If you have ever wondered what does HCl mean on a prescription, it signifies a chemical modification that dramatically improves the drug's properties for therapeutic use.

Over half of all medicines are formulated as salts, with hydrochloride being the most common, found in 15.5% of all drugs [1.8.1]. But what is hydrochloride? It is not an active drug, but a crucial component that enhances the properties of many common medications [1.2.2, 1.3.1].