Tag: Splenomegaly

Splenomegaly, or enlargement of the spleen, can occur as a side effect of numerous medications, with some chemotherapy patients seeing a more than 30% increase in spleen volume. Understanding **what drugs cause spleen enlargement** is crucial for patients and clinicians to recognize, diagnose, and manage this adverse reaction. Often, symptoms are subtle or nonexistent, but in some cases, drug-induced splenomegaly can lead to serious complications.

Myelofibrosis is a complex bone marrow cancer characterized by overactive Janus kinase (JAK) signaling, which leads to the formation of scar tissue. Jakafi is a targeted therapy designed to address this underlying mechanism by inhibiting key JAK proteins.