Tag: Ssri side effects

In 2023, sertraline (the generic name for Zoloft) accounted for 16.7% of all antidepressant prescriptions in the U.S. [1.7.1]. While effective for many, a common question is: can Zoloft cause leg cramps? The answer is yes, this can be a side effect [1.2.3, 1.2.4].

Breast tenderness or enlargement is a less common or rare side effect associated with the use of sertraline. While not experienced by most users, this potential adverse effect is well-documented in medical literature and can be linked to hormonal changes induced by the medication. Understanding the reasons behind this side effect can help individuals manage their symptoms and decide the best course of action with their healthcare provider.

Gastrointestinal (GI) side effects are a common adverse reaction for many second-generation antidepressants, with diarrhea being a frequently reported issue. Research indicates that certain selective serotonin reuptake inhibitors (SSRIs), notably sertraline (Zoloft), have a higher propensity to induce this symptom, often during the initial weeks of treatment. Understanding which antidepressant causes diarrhea can help patients and doctors navigate this challenge effectively.

According to clinical trial data, approximately 22% of individuals taking Prozac experience nausea, a significantly higher rate than those on a placebo. The reason **does Prozac cause gastrointestinal problems** is linked to how the medication increases serotonin levels, with the majority of the body's serotonin receptors located in the gut. This can cause noticeable digestive changes, particularly during the first weeks of treatment.

Approximately 12-20% of the body's serotonin is produced in the gastrointestinal tract, and because antidepressants influence this key neurotransmitter, they can significantly affect digestive function. This raises the question: do antidepressants affect stomach acid and other gastric processes?

According to a network meta-analysis of multiple randomized controlled trials, sertraline had the highest probability of digestive system side effects compared to other common SSRIs. This is a critical factor when addressing the common concern of which SSRI has the most GI side effects, as these issues can lead to poor medication adherence.

In clinical trials for Major Depressive Disorder, 15% of Lexapro users reported nausea [1.6.1]. A related, though less discussed, side effect is heartburn. So, **can Lexapro cause heartburn?** Yes, it is a documented side effect linked to its impact on the digestive system [1.2.1, 1.2.4, 1.2.5].

According to a 2025 study, SSRIs like Zoloft are associated with an increased risk of gastrointestinal issues, including heartburn. If you experience this side effect, understanding **what antacid is safe with Zoloft** is critical for your health and to avoid dangerous drug interactions, especially concerning heart rhythm.

While the true incidence of serotonin syndrome is unknown because many cases go unrecognized, it's a serious condition that can develop rapidly [1.6.1]. Symptoms can appear within minutes or hours of taking a new medication or increasing a dose [1.2.1]. This article explains how quickly does serotonin syndrome appear, its symptoms, and causes.

In clinical trials, about 8% of adults taking Lexapro for major depressive disorder or generalized anxiety disorder reported diarrhea [1.3.1, 1.6.1]. For many, this side effect is temporary, but knowing **how long will diarrhea last on Lexapro** can help manage expectations.