Tag: Step down therapy

With mortality rates increasing by about 8% for every hour that effective antibiotic therapy is delayed in septic shock, speed and potency are critical. While initial treatment for severe sepsis and septic shock mandates intravenous (IV) broad-spectrum antibiotics, the question of what is the best oral antibiotic for sepsis pertains to subsequent 'step-down' therapy for stable, recovering patients.

Neonatal infections account for 22% of all deaths in children under five, making effective antibiotic treatment critical. This article explores the question: What oral antibiotics are used in neonates for conditions not requiring initial intravenous therapy or as step-down treatment?