Can long term PPI use cause gastroparesis? Separating the Connection from the Condition
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4 min read
According to one report, up to 40% of patients with gastroesophageal reflux disease (GERD) may also have associated gastroparesis or delayed gastric emptying. This raises a critical question for many: **can long term PPI use cause gastroparesis**? While PPIs are known to slow gastric emptying, medical evidence suggests they typically exacerbate, rather than directly cause, the underlying nerve or muscle damage defining gastroparesis.