Tag: Stress hormone

Studies reveal that many individuals with depression exhibit dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol production [1.8.2]. This raises a critical question for treatment: **Does amitriptyline affect cortisol levels** as part of its therapeutic mechanism?

Major Depressive Disorder (MDD) is often linked to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, the body's central stress response system [1.4.5, 1.8.5]. A key question for many is, **does sertraline affect your cortisol levels** as part of its therapeutic action? The answer is complex and depends on several factors.

Caffeine consumption can significantly increase levels of cortisol, the body's primary stress hormone, with coffee eliciting the strongest response [1.3.3, 1.3.4]. Understanding what supplements raise cortisol levels is crucial for managing stress and overall health.

Despite some antidepressants showing a cortisol-lowering effect, research suggests that Wellbutrin (bupropion) does not consistently reduce cortisol levels and may even temporarily increase them in some individuals. This atypical effect is linked to its unique mechanism of action on norepinephrine and dopamine.