Understanding the Link: Does Amitriptyline Lower Cortisol Levels?
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5 min read
Chronic stress and depression are frequently associated with a dysregulated hypothalamic-pituitary-adrenal (HPA) axis, leading to persistently elevated cortisol levels. A central question in psychopharmacology is whether older antidepressants, including amitriptyline, can help normalize this system and, in doing so, does amitriptyline lower cortisol levels.