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Tag: Systemic estrogen

Explore our medication guides and pharmacology articles within this category.

What is the black box warning on estradiol? Understanding the risks and ongoing controversy

3 min read
For over two decades, all estrogen-containing medications prescribed for menopausal women have carried a U.S. Food and Drug Administration (FDA) **black box warning on estradiol** and other estrogens. This warning, originating from a pivotal 2002 study, cautions about potential risks associated with systemic hormone therapy, though its broad application to all estrogen products has become a significant source of controversy.