Tag: Tachykinin

Recent research has identified the neurokinin 2 receptor (NK2R) as a promising target for metabolic diseases, with selective long-acting agonists reversing cardiometabolic issues in macaques [1.6.4]. So, **what are neurokinin 2 receptor agonists** and how do they function?

The neurokinin 2 (NK2) receptor, a member of the tachykinin receptor family, is predominantly found on smooth muscle in the periphery, including the gastrointestinal, respiratory, and urinary tracts. A range of compounds, known as neurokinin 2 receptor antagonists, have been developed to block the action of the endogenous ligand neurokinin A (NKA) at these receptors, though many have failed to reach the market despite initial promise.