Tag: Tca side effects

Approximately 12-20% of the body's serotonin is produced in the gastrointestinal tract, and because antidepressants influence this key neurotransmitter, they can significantly affect digestive function. This raises the question: do antidepressants affect stomach acid and other gastric processes?

According to prescribing information and medical sources like Drugs.com, diarrhea is a known, though less common, gastrointestinal side effect of amitriptyline. Though it is more famously associated with constipation due to its anticholinergic properties, it's important for patients to understand the full range of potential GI reactions to this medication.