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Tag: Tca toxicity

Explore our medication guides and pharmacology articles within this category.

What Happens if You Have Too Much Amitriptyline?

4 min read
Tricyclic antidepressants like amitriptyline have a narrow therapeutic index, meaning the difference between a therapeutic dose and a toxic dose is relatively small, making an overdose a life-threatening event. A toxic amount of amitriptyline can disrupt the heart's electrical system, cause severe neurological symptoms, and lead to coma or death if not treated promptly.