Tag: Tdf

While older HIV treatments containing tenofovir disoproxil fumarate (TDF) were more commonly associated with kidney toxicity, **Biktarvy** uses a newer, safer form of tenofovir that significantly reduces this risk. However, like many medications, it is not without risk, and instances of new or worsening kidney problems have been reported.

In a 2012 study, researchers found that for each year HIV-positive patients took the tenofovir disoproxil fumarate (TDF) contained in Truvada, their risk of chronic kidney disease increased by 33%. This has led many to question: **Does Truvada affect the kidneys?**. The answer is yes, particularly with long-term use, and understanding this impact is crucial for patient care and monitoring.

While tenofovir is a highly effective antiviral drug, its different formulations have distinct safety profiles. A key question for patients and clinicians is which of the following side effects is common with tenofovir, particularly when comparing the older tenofovir disoproxil fumarate (TDF) and the newer tenofovir alafenamide (TAF). The answer depends heavily on the specific formulation and individual patient factors.

First approved by the FDA in 2006, branded Atripla was discontinued by its manufacturer, Gilead Sciences, toward the end of 2021. The decision to remove the branded medication from the market was driven primarily by commercial factors and diminishing demand, not by concerns over its effectiveness or a sudden discovery of new safety issues.

Tenofovir is a nucleotide reverse transcriptase inhibitor (NRTI) that is a mainstay of many antiretroviral therapy combinations. People who take tenofovir do so for several crucial reasons, most commonly for the treatment of Human Immunodeficiency Virus (HIV) infection, the management of chronic Hepatitis B (HBV) infection, or for HIV prevention, known as pre-exposure prophylaxis (PrEP).

Clinical trials, such as the DISCOVER trial, have shown that Descovy is associated with improved renal biomarkers compared to Truvada. This critical finding leads many to ask: is Descovy better for kidneys than Truvada? The answer lies in the different versions of the tenofovir drug they contain and individual patient health factors.

Yes, older formulations of the medication tenofovir, specifically tenofovir disoproxil fumarate (TDF), have been definitively linked to an increased risk of kidney problems, from a mild, predictable decline in function to more severe conditions like Fanconi syndrome. The development of a newer prodrug, tenofovir alafenamide (TAF), aimed to address these concerns by significantly reducing the drug's plasma concentration.

Tenofovir disoproxil fumarate (TDF) is an antiretroviral medication FDA-approved for treating HIV-1 and chronic hepatitis B (HBV) in children aged two years and older. So, is tenofovir given to children? Yes, under specific guidelines and with careful monitoring.

Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir, formulated to deliver the active antiviral agent to target cells more efficiently and at a much lower dose than its predecessor, tenofovir disoproxil fumarate (TDF) [1.2.2]. The central question for clinicians and patients is: Is tenofovir alafenamide better than tenofovir disoproxil fumarate?

With modern antiviral therapies transforming the management of viral diseases, tenofovir is a mainstay in treating HIV and hepatitis B infections. So, what are tenofovir tablets used for, and how do its different formulations provide effective options for patients? This article explores its applications, formulations, and critical considerations.