Tag: Testosterone replacement therapy

In a clinical study involving patients on Xyosted, over 90% of participants achieved testosterone levels within the normal range by week 12, demonstrating its efficacy. So, what is Xyosted used for and how does this weekly, self-administered injection work to treat hypogonadism?

In recent years, injectable testosterone products have been a prominent choice for patients, accounting for a significant majority of all testosterone prescriptions filled. For those considering this option, a common question is, is there a generic for testosterone enanthate injection? The answer is yes, though it depends on the specific formulation you are prescribed.

As of late 2025, the brand-name medication Xyosted is exclusively available without a generic version. This means patients needing testosterone replacement therapy via its specific autoinjector system must rely on the branded product and related support programs to help manage costs.

Despite being used for the same purpose—treating low testosterone levels in men—Xyosted and testosterone cypionate are fundamentally different medications. The core distinctions lie in their active ingredient, method of administration, and dosing schedule, all of which significantly impact the patient experience.

Globally, the lifetime prevalence of anabolic-androgenic steroid use is 6.4% for males [1.9.2]. A primary concern for users and prescribers has been liver safety, begging the question: **Is oral testosterone hard on the liver?** The answer depends entirely on the type of oral testosterone in question.

While many supplements are marketed to boost testosterone, genuine testosterone replacement therapy is only available via prescription from a licensed healthcare provider. This means you will not find an actual, clinically proven over the counter testosterone pill containing the hormone itself. Instead, OTC options consist of unproven herbal and vitamin blends.

Recent clinical research has shown that modern oral testosterone formulations, like testosterone undecanoate (Jatenzo, Tlando, Kyzatrex), can be an effective alternative to traditional injections for raising testosterone levels. While older oral variants were associated with liver toxicity, newer pills are designed to bypass the liver, providing a safer option. This offers patients a new choice, though each delivery method has distinct differences in dosing, cost, and stability of hormone levels.

According to the Endocrine Society, low testosterone affects up to 40% of men over the age of 45. This prevalence has led many to ask: **Do testosterone pills really work?** The answer depends entirely on whether you are referring to an FDA-approved prescription or an over-the-counter (OTC) supplement.

Hypogonadism, or low testosterone, affects an estimated 4 to 5 million men in the United States, yet only about 5% receive treatment [1.8.5]. The question for many is: **are oral testosterone pills effective** and safe for managing this condition?

In a 2008 interview with *Time* magazine, Sylvester Stallone publicly advocated for the use of testosterone, stating that "Everyone over 40 years old would be wise to investigate it because it increases the quality of your life". His use of hormone therapy, including testosterone and human growth hormone (HGH), has been a matter of public record and controversy, prompting many to ask: **Does Sylvester Stallone do TRT**?