Tag: Tight junctions

The blood-brain barrier (BBB) is a highly selective semi-permeable membrane that protects the central nervous system, and approximately 98% of all small-molecule drugs fail to cross it. Understanding what are the factors controlling permeability of the blood brain barrier is crucial for developing effective medications for neurological disorders.

Approximately 98% of small-molecule drugs and 100% of large-molecule drugs are unable to cross the blood-brain barrier (BBB). This specialized cellular boundary acts as a gatekeeper, restricting the distribution of a vast range of substances from the bloodstream into the central nervous system to protect the brain's delicate environment.