Tag: Topical calcineurin inhibitors

Over 20 years of data show that topical tacrolimus (Protopic) has a well-established safety profile for atopic dermatitis, but like all effective medications, it requires proper application. It is vital to understand *where not to use tacrolimus ointment* and under which circumstances to ensure its safe and effective use.

Globally, eczema affects 10% to 20% of children and up to 10% of adults [1.9.1, 1.9.4]. Finding the best anti-inflammatory for eczema depends on severity, location, and patient age, with options ranging from over-the-counter creams to advanced systemic drugs.

Studies show topical tacrolimus has minimal systemic absorption, especially as the skin's barrier function improves during treatment. This is a crucial distinction from its oral counterpart, which is used for organ transplant patients and has potent, widespread immunosuppressive effects. The immunosuppressive effect of topical tacrolimus is primarily local, focused on reducing inflammation in the treated skin area.

According to prescribing information, Picon cream contains the active ingredient pimecrolimus, a non-steroidal immunosuppressant. This makes it a distinct alternative to corticosteroid creams for treating inflammatory skin conditions like mild to moderate atopic dermatitis.