Tag: Topical clindamycin

Minimal systemic absorption occurs with topical clindamycin, a fact established by studies confirming the drug's presence in urine but not consistently in the bloodstream after application. This means that while some of the medication enters your system, the amount is significantly less than with oral antibiotics, which directly impacts how long topical clindamycin stays in your system and its systemic effects.

While less common than with oral antibiotics, cases of *C. difficile* infection have been documented following the use of topical clindamycin, a fact highlighted in various case reports. This potential, albeit small, stems from the medication's limited systemic absorption, which can disrupt the gut microbiome. Understanding this risk is crucial for patient safety.