Tag: Toxic epidermal necrolysis

Lamotrigine, a medication used for epilepsy and bipolar disorder, carries a black box warning from the FDA due to a rare but serious risk of developing a severe, life-threatening skin rash. For this reason, the most feared and potentially the biggest side effect of lamotrigine is the development of a severe cutaneous adverse reaction.

While millions safely take Tylenol (acetaminophen) daily, the FDA has warned that, in rare instances, **can Tylenol cause red spots on skin** or other serious, potentially fatal, skin reactions. These adverse events, known as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Acute Generalized Exanthematous Pustulosis (AGEP), are hypersensitivity reactions and require immediate medical attention.

Allopurinol hypersensitivity syndrome (AHS) is a severe adverse drug reaction that affects approximately 1 in 1000 patients prescribed allopurinol, carrying a reported mortality rate between 20% and 25%. To answer the question, what is the most serious side effect on the use of allopurinol? It is this rare yet devastating allergic reaction, and understanding its early signs and risk factors is crucial for minimizing its danger.