Tag: Transport mechanisms

The blood-brain barrier (BBB) is a highly selective gatekeeper that protects the central nervous system from circulating toxins and pathogens. While it effectively blocks most substances, certain small, lipid-soluble molecules **can freely pass through the blood-brain barrier** via passive diffusion, a critical factor in neuropharmacology.

The blood-brain barrier (BBB) prevents entry of over 98% of small-molecule drugs and virtually all large-molecule therapeutics into the brain. Understanding what are the transport routes across the blood brain barrier is therefore critical for developing effective medications for central nervous system disorders.