Tag: Treatment resistant ocd

For the 40–60% of patients with obsessive-compulsive disorder (OCD) who fail to respond adequately to standard medication, augmentation with an antipsychotic may be considered. Determining **what is the best antipsychotic for OCD** involves weighing several factors, as there is no single best option for all patients and they are not used as first-line treatment.

While no single new drug has recently received widespread FDA approval specifically for obsessive-compulsive disorder (OCD) in 2025, a robust pipeline of investigational treatments is targeting refractory cases. For the approximately 40–60% of patients who do not respond adequately to first-line serotonin reuptake inhibitors (SSRIs), researchers are focusing on alternative neurobiological pathways, most notably the glutamate system.