Tag: Treatment resistant psychosis

An estimated 1.6% of U.S. adults use antipsychotic medications, which are crucial for managing psychosis [1.7.1]. When determining 'What is the strongest antipsychotic for psychosis?', it is essential to distinguish between potency and efficacy, with clozapine recognized for its superior effectiveness in treatment-resistant cases [1.2.1, 1.2.3].

According to one study, approximately 18% of patients discharged from US state psychiatric hospitals who were prescribed an antipsychotic were taking more than one. The practice of using two antipsychotics at the same time, known as polypharmacy, is generally discouraged by most clinical guidelines but is sometimes used cautiously in specific, difficult-to-treat cases.

Up to one-third of people with schizophrenia do not respond adequately to initial antipsychotic medications, a condition known as treatment-resistant schizophrenia (TRS). This article explores which is the most effective antipsychotic for resistant psychotic symptoms, detailing the evidence-backed approach to managing this complex condition.