Tag: Trimethylglycine

For many individuals, the timing of supplement intake can be as important as the supplement itself. This is especially true for Trimethylglycine (TMG), leading many to wonder, **should I take TMG before bed?**

According to Examine.com, supplementing with betaine (TMG) reliably reduces homocysteine levels in humans, which influences various bodily functions. Understanding **what does TMG make you feel like** requires examining its role in methylation, which can lead to noticeable changes in energy, mood, and physical performance.

Studies show that taking up to 4 grams of Trimethylglycine (TMG) daily can lower homocysteine levels, a factor linked to cardiovascular health [1.2.1, 1.3.5]. But when it comes to the complex question, 'Does TMG raise blood pressure?', the answer is nuanced, with evidence pointing toward both potential benefits and risks.

While betaine, or trimethylglycine (TMG), is generally well-tolerated at moderate doses, research shows that high intake, especially via supplementation, can cause various side effects and carries serious risks in specific medical contexts.

While some individuals report noticing improved energy and reduced fatigue from TMG within days or weeks, more significant, cumulative effects on cardiovascular and liver health can take several months to manifest. The answer to how long it takes to see results from TMG is not a single timeline but depends heavily on your specific health goals and individual biochemistry.

Clinical studies have consistently shown that trimethylglycine (TMG), also known as betaine, can significantly lower elevated levels of the amino acid homocysteine in the blood. This vital process can have important implications for overall cardiovascular and metabolic health by modulating key biochemical pathways. This article explains precisely **how does TMG affect homocysteine** metabolism.

In a 2021 study involving isolated rat pulmonary artery rings, betaine demonstrated concentration-dependent vasodilatory effects through an endothelium-dependent mechanism involving inward rectifier potassium channels. Building on this and other research, the question "Is betaine a vasodilator?" warrants a nuanced answer, exploring its indirect pathways through metabolism and its potential impact on cardiovascular health.