Tag: Tubular secretion

In a healthy person, up to 90% of a penicillin dose is excreted in the urine, with 60% eliminated within the first hour [1.4.1, 1.3.1]. So, how does penicillin leave the body so efficiently? The answer lies in a highly active process within the kidneys.

The renal clearance of penicillin G in normal individuals is predominantly via the kidney, a process so rapid that its serum half-life is remarkably short. This rapid elimination is why understanding how is penicillin eliminated by the kidneys is crucial for appropriate dosing and treatment efficacy.

In adults with normal renal function, the plasma half-life of penicillin G is only about 30–60 minutes, highlighting its rapid processing by the body [1.2.2]. Understanding how is penicillin metabolized in the body is crucial for effective antibiotic therapy and dosage management.