Tag: Tyramine reaction

Explore our medication guides and pharmacology articles within this category.

Is Phenelzine a Reversible MAOI? Unpacking its Irreversible Action

Oct 14, 2025 •

3 min read

Phenelzine (Nardil) is one of the oldest antidepressant medications still in clinical use today, known for its potent and irreversible action on monoamine oxidase. This article clarifies why **phenelzine is an irreversible MAOI**, detailing the significant pharmacological and clinical implications of this classification for patients and healthcare providers.

Are MAOIs permanent? Understanding Irreversible vs. Reversible Inhibition

Oct 13, 2025 •

4 min read

First used in the 1950s, Monoamine Oxidase Inhibitors (MAOIs) were among the earliest antidepressants developed [1.7.1]. The answer to 'Are MAOIs permanent?' depends on the type, as some bind irreversibly to enzymes, requiring the body to create new ones over several weeks [1.3.5, 1.4.1].