Tag: Unisom and bupropion

Explore our medication guides and pharmacology articles within this category.

Can I Take Unisom with Bupropion? A Guide to Risks and Interactions

Oct 10, 2025 •

4 min read

Approximately 80% of patients with depression report symptoms of insomnia [1.8.1, 1.8.4]. If you're taking an antidepressant like bupropion, you might wonder, 'Can I take Unisom with bupropion to help me sleep?' This combination requires significant caution and medical guidance.