Why Avoid Folic Acid with MTHFR?: Understanding the MTHFR Gene and Folate Metabolism
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4 min read
According to one recent study, excess synthetic folic acid intake in people with the MTHFR C677T variant can lead to the accumulation of unmetabolized folic acid (UMFA), which is associated with cognitive and psychiatric issues. This critical genetic variation highlights the fundamental difference between the body's processing of synthetic folic acid and natural folate, and why avoiding folic acid with MTHFR is a key consideration for many people.
