Tag: Unopposed estrogen

According to the American Cancer Society, taking estrogen alone with an intact uterus can dramatically increase the risk of endometrial cancer, highlighting the critical role of progesterone. Understanding **what happens if I don't take progesterone with HRT** is essential for any woman considering or currently on hormone replacement therapy.

Taking estrogen without a progestin increases the risk of endometrial cancer by up to 50% in women with an intact uterus within the first year of use. Therefore, the question of 'can I take estrogen alone?' depends heavily on a person's medical history, specifically if they have had a hysterectomy.