Tag: Vascular calcification

While most commonly known for its anticoagulant properties, warfarin can, in rare cases, trigger the devastating condition of calciphylaxis. The mechanism behind this serious adverse effect is linked to the medication's interaction with vitamin K, which impacts not only clotting factors but also proteins that prevent vascular calcification.

Calciphylaxis is a rare but severe condition affecting 1-4% of patients with end-stage renal disease (ESRD), with a one-year mortality rate that can exceed 50% [1.3.7, 1.6.2]. The question of whether vitamin D can cause calciphylaxis is complex, as it is considered a significant contributing factor, especially in susceptible individuals [1.2.1, 1.3.1].

Vascular calcification is a significant predictor for the development of coronary heart disease [1.7.1]. While no single medication definitively removes all types of calcification, several pharmacological approaches aim to manage or slow its progression. This article reviews what medication is used to remove calcification in various forms.