Tag: Vmat inhibitor

Derived from the root of the *Rauwolfia serpentina* plant, reserpine was one of the earliest medications used in modern medicine to treat hypertension and certain psychiatric conditions. The primary therapeutic effect of reserpine is achieved by depleting monoamine neurotransmitters from nerve endings, which effectively lowers blood pressure and has a sedative, tranquilizing effect.

Approved in the U.S. in 1955, reserpine was a foundational antihypertensive medication [1.2.4, 1.3.5]. So, **why is reserpine not used clinically** today? The answer lies in its challenging side effect profile and the development of more tolerable and potent alternatives [1.2.4].