Tag: Women s health initiative

According to the landmark Women's Health Initiative (WHI) study, postmenopausal women using combined estrogen and medroxyprogesterone (the active ingredient in Provera) experienced a 41% higher risk of stroke compared to those on a placebo. This established a significant link between combination hormone therapy and elevated cardiovascular risk, including stroke.

Following the 2002 publication of the Women's Health Initiative (WHI) study, hormone replacement therapy (HRT) prescriptions plummeted by over 50% globally, leaving many doctors with a lasting caution. This caution and sometimes outright aversion are not simply due to one flawed study but are shaped by a complex interplay of historical evidence, patient-specific risks, and the evolution of medical guidelines, which sheds light on why doctors not like hormone replacement therapy.