Tag: Xenobiotics

The human genome encodes for five functional flavin-containing monooxygenase (FMO) enzymes, which play a significant role in the body's defense against potentially harmful foreign chemicals. These enzymes are primarily responsible for detoxifying and metabolizing a diverse range of drugs and xenobiotics, converting them into more water-soluble forms for excretion.

Did you know that an estimated 40-70% of all clinically used drugs are eliminated from the body through the process of glucuronidation? This vital metabolic pathway is a key player in both detoxification and drug elimination, ensuring that waste products and foreign substances don't accumulate to toxic levels.

Did you know that the cytochrome P450 family of monooxygenases is responsible for metabolizing approximately 75% of all drugs currently on the market? These crucial enzymes catalyze the incorporation of a single oxygen atom from molecular oxygen into a vast array of substrates, facilitating vital biochemical transformations throughout the body.

Over 70% of all drugs in clinical use are metabolized by Cytochrome P450 (CYP450) enzymes, a complex and vital system in the body. These enzymes play a crucial role in processing both medications and other foreign substances, profoundly affecting how our bodies respond to various drugs.