What is Cefotetan?
Cefotetan is a sterile, semisynthetic, broad-spectrum antibiotic belonging to the cephalosporin (specifically, cephamycin) class of medications [1.8.2]. Administered parenterally, either intravenously (into a vein) or intramuscularly (into a muscle), it is effective against a wide range of aerobic and anaerobic gram-positive and gram-negative bacteria [1.4.2]. Its primary mechanism of action is inhibiting bacterial cell wall synthesis, which ultimately kills the bacteria [1.4.2, 1.4.5].
Commonly sold under the brand name Cefotan, it is prescribed for various infections, including [1.8.6]:
- Urinary tract infections
- Lower respiratory tract infections
- Skin and skin structure infections
- Gynecologic and intra-abdominal infections
- Bone and joint infections
Additionally, cefotetan is frequently used for surgical prophylaxis, administered 30 to 60 minutes before procedures like abdominal or vaginal hysterectomy, biliary tract surgery, and cesarean sections to prevent postoperative infections [1.8.6].
Factors Influencing the Cost of Cefotetan in the USA
The price patients pay for cefotetan can vary significantly based on several key factors:
Pharmacy and Location
Prices for the same medication can differ dramatically from one pharmacy to another. For example, with a discount coupon, the price for cefotetan can range from as low as $24.80 at an HEB Pharmacy to $39.85 at Walmart or $40.55 at Walgreens [1.3.1]. In some cases, the price at a major chain like CVS can be substantially higher without discounts [1.3.1].
Dosage and Formulation
Cefotetan is typically supplied as a powder for injection in vials, commonly in 1g or 2g strengths [1.8.2]. The total cost of treatment depends on the prescribed dose and the duration of therapy. A supply of 10 units of injectable powder for injection might cost around $414.70, with a per-unit price of approximately $41.47 [1.2.1]. The brand name, Cefotan, can sometimes be more expensive, with a similar quantity costing around $500.78 [1.2.3].
Insurance Coverage
The extent of a patient's prescription drug coverage through their health insurance plan is one of the most significant cost determinants. The final out-of-pocket expense will depend on copayments, deductibles, and whether the drug is on the formulary.
Discount Cards and Patient Assistance
For uninsured or underinsured patients, prescription discount cards can offer substantial savings. For instance, prices can drop to the $25-$45 range at various pharmacies with a coupon [1.3.1]. While there are no specific, manufacturer-run patient assistance programs solely for cefotetan, broader programs from organizations like the Teva Cares Foundation or Takeda's Help At Hand provide certain medications at no cost to eligible individuals based on income and insurance criteria [1.6.3, 1.6.4].
Cefotetan vs. Other Cephalosporins
Cefotetan is often compared to other antibiotics in its class, particularly cefoxitin, for both efficacy and cost. Both are effective in treating similar types of infections, including intra-abdominal and gynecological infections [1.5.1, 1.5.3].
| Feature | Cefotetan | Cefoxitin |
|---|---|---|
| Dosing Frequency | Often administered twice daily (every 12 hours) due to a longer half-life of about 3.5 hours [1.4.6, 1.8.6]. | Typically requires more frequent administration (e.g., three doses) [1.5.5]. |
| Spectrum of Activity | Broad-spectrum activity against many aerobic and anaerobic bacteria; highly resistant to beta-lactamases [1.4.2]. | Effective against many of the same pathogens, including Bacteroides fragilis [1.5.3]. |
| Cost-Effectiveness | Studies have suggested cefotetan can be more cost-effective than cefoxitin, partly due to less frequent dosing, which reduces administration time and supplies [1.5.2, 1.5.5]. | May have a lower acquisition cost per dose, but overall therapy cost can be higher due to more frequent administration [1.2.7, 1.5.2]. |
| Surgical Prophylaxis | A single preoperative dose has been shown to be as safe and effective as multiple doses of cefoxitin for certain procedures like colorectal surgery and hysterectomy [1.5.4, 1.5.6]. | Often requires multiple doses for effective surgical prophylaxis [1.5.4]. |
Important Safety Considerations
Like all antibiotics, cefotetan has potential side effects. Common ones include diarrhea, nausea, and pain or swelling at the injection site [1.7.2]. More serious, though less common, side effects can occur, such as severe Clostridium difficile-associated diarrhea, allergic reactions, and liver or kidney damage [1.7.2, 1.7.6]. A rare but serious risk associated with cefotetan is immune-mediated hemolytic anemia, a condition where red blood cells are destroyed [1.8.2, 1.8.6]. It's also important to avoid alcohol while taking cefotetan and for 72 hours after the last dose, as it can cause a severe reaction including headache, sweating, and a fast heartbeat [1.4.1, 1.7.1].
Conclusion
The question of 'how much is cefotetan in the USA?' does not have a single answer. The cost is highly variable, influenced by the pharmacy, dosage, insurance plan, and the use of discount programs. Without insurance, the price can be substantial, but coupons and discount cards can lower the out-of-pocket expense to under $50 for a given unit [1.3.1]. Clinically, cefotetan remains a vital antibiotic for treating serious bacterial infections and preventing them during surgery. Its longer half-life often makes it a cost-effective alternative to other antibiotics like cefoxitin by reducing administration frequency [1.5.2]. Patients should always discuss costs and potential side effects with their healthcare provider and pharmacist to ensure they receive the most appropriate and affordable treatment.
For more detailed drug information, consult the FDA label or a trusted medical source.
Disclaimer: This article is for informational purposes only and does not constitute medical advice. Consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.
Authoritative Link: Cefotetan Drug Information from the FDA [1.8.6]
