What is Distaclor (Cefaclor)?
Distaclor is a brand name for the antibiotic cefaclor [1.2.6]. It belongs to a class of medications known as second-generation cephalosporin antibiotics [1.2.4]. Cefaclor was patented in 1973 and approved for medical use in 1979 [1.2.4]. It functions by inhibiting the growth of bacteria, specifically by preventing them from building their protective cell walls, which ultimately leads to bacterial cell death [1.4.2, 1.4.6]. It's important to note that like all antibiotics, cefaclor is only effective against bacterial infections and will not work for viral illnesses such as the common cold or flu [1.2.1].
How is Strength Determined? The Spectrum of Activity
The term 'strong' when applied to an antibiotic is subjective and depends on the context, particularly the type of bacteria causing the infection. A more precise way to evaluate an antibiotic's power is by its 'spectrum of activity.' Cefaclor is considered a broad-spectrum antibiotic, meaning it is active against a wide variety of both Gram-positive and Gram-negative bacteria [1.2.6, 1.4.1].
As a second-generation cephalosporin, it has a broader spectrum against certain Gram-negative bacteria compared to first-generation cephalosporins like cephalexin (Keflex) [1.8.2]. However, it is less active against Gram-negative bacteria than third-generation cephalosporins [1.3.4]. Its activity includes common pathogens such as:
- Staphylococcus aureus
- Streptococcus pneumoniae
- Streptococcus pyogenes
- Haemophilus influenzae
- Escherichia coli
- Klebsiella spp.
- Proteus mirabilis
This makes it a moderately potent choice for many common infections, though it may not be the primary option for infections caused by highly resistant bacteria [1.3.4, 1.4.6].
Common Uses for Cefaclor
Clinicians prescribe cefaclor for a range of bacterial infections. Its specific indications often include [1.2.1, 1.5.1, 1.5.2]:
- Lower Respiratory Tract Infections: Such as pneumonia and bronchitis [1.5.1].
- Upper Respiratory Tract Infections: Including pharyngitis (sore throat) and tonsillitis [1.5.1].
- Otitis Media: Infections of the middle ear [1.5.4].
- Skin and Skin Structure Infections: Caused by susceptible strains of Staphylococcus and Streptococcus [1.5.4].
- Urinary Tract Infections (UTIs): Including pyelonephritis and cystitis [1.5.1].
Comparison with Other Common Antibiotics
To better understand cefaclor's relative strength and role, it's helpful to compare it to other frequently prescribed antibiotics.
| Feature | Cefaclor (Distaclor) | Amoxicillin | Cephalexin (Keflex) |
|---|---|---|---|
| Class | 2nd-Gen Cephalosporin [1.2.4] | Aminopenicillin [1.7.5] | 1st-Gen Cephalosporin [1.8.1] |
| Spectrum | Broad; Gram-positive and some Gram-negative coverage [1.3.4] | Broad; primarily Gram-positive and some Gram-negative [1.7.5] | Primarily Gram-positive with limited Gram-negative activity [1.8.2] |
| Key Advantage | Better activity against H. influenzae than 1st-gen cephalosporins [1.8.2] | Well-established, often first-line for many infections [1.7.2] | Effective for skin infections and strep throat [1.8.2] |
| Common Uses | Ear infections, bronchitis, UTIs, skin infections [1.5.1] | Ear infections, strep throat, pneumonia, skin infections [1.7.5] | Skin infections, bone infections, UTIs, respiratory infections [1.8.1] |
Potential Side Effects and Precautions
Like all medications, cefaclor can cause side effects. Common side effects are generally mild and may include diarrhea, nausea, headache, and vaginal itching [1.2.1, 1.6.2]. More serious, though less common, side effects can occur, such as severe stomach pain, watery or bloody stools, fever, joint pain, or signs of a severe allergic reaction like hives, difficulty breathing, or swelling of the face and throat [1.6.2].
Patients should inform their doctor of any allergies, especially to penicillin or other cephalosporin antibiotics, as cross-reactivity can occur [1.6.1]. It's also important to disclose any history of kidney disease or gastrointestinal issues like colitis [1.2.1]. Cefaclor may interact with other medications, including certain antacids and oral anticoagulants (blood thinners) [1.6.1].
Conclusion: Is Distaclor a Strong Antibiotic?
Distaclor (cefaclor) is a moderately strong, broad-spectrum antibiotic that is effective for a specific range of common bacterial infections [1.2.6, 1.3.4]. Its 'strength' lies in its classification as a second-generation cephalosporin, which gives it reliable activity against many common respiratory and skin pathogens [1.3.1]. While newer generations of antibiotics may offer coverage for more resistant bacteria, cefaclor remains a valuable and effective treatment option when used appropriately for susceptible infections. The decision to use it depends on the specific bacteria identified or suspected by a healthcare professional.
For more detailed information, you can consult the Cefaclor page on MedlinePlus, an authoritative source for patient medication information. [1.2.1]
