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Understanding the most used federally illegal drug and its implications

3 min read

According to the Centers for Disease Control and Prevention (CDC), over 52 million Americans used cannabis in 2021, making it the most used federally illegal drug in the United States. While its federal status remains unchanged, widespread state-level legalization and cultural shifts have led to increased usage and complex public health considerations regarding marijuana.

Quick Summary

Cannabis is the most widely used federally illegal substance, with millions of users globally and in the U.S. This widespread use presents complex public health challenges, especially considering its evolving legal status and potential health impacts.

Key Points

  • Cannabis is the most widely used federally illegal drug: Statistics show marijuana use significantly outpaces other federally controlled substances like cocaine and heroin in the United States and globally.

  • Legal status is complex and conflicting: Despite federal prohibition under Schedule I of the Controlled Substances Act, numerous U.S. states have legalized cannabis for medical and/or recreational use, creating a legal gray area.

  • Usage rates are rising: The increasing accessibility and changing public perception of marijuana have led to a steady increase in usage rates over the past decades.

  • Marijuana use is associated with health risks: Chronic use, especially when starting young, can impact brain development, mental health, and lead to dependency, respiratory issues, and other health problems.

  • High-potency products pose new concerns: The THC concentration in cannabis products has dramatically increased, potentially contributing to higher rates of adverse health effects and addiction.

In This Article

Marijuana: The Most Used Federally Illegal Drug

Data from various sources consistently shows that marijuana, or cannabis, is the most commonly used federally illegal drug both in the U.S. and worldwide. Despite numerous states legalizing it for medical or recreational purposes, it is still classified as a Schedule I controlled substance under federal law, indicating a high potential for abuse and no accepted medical use. This federal classification creates a notable contrast with the widespread use and regulated state markets.

In the U.S., recent data from 2024 indicates that over 64 million Americans used marijuana in the past year, significantly more than other illicit substances. This aligns with a long-term trend of increasing numbers of Americans reporting having tried marijuana. Globally, the United Nations Office on Drugs and Crime (UNODC) has also identified cannabis users as the largest group of illicit drug users historically. A 2023 analysis reported 244 million global cannabis users, far exceeding users of other substances.

Comparison of Federally Illegal Drug Usage in the U.S. (Past Year, 2024)

Drug Estimated Number of Users (in 1,000s) Global Comparison Primary Risk Federal Schedule
Marijuana 64,194 Most widely used globally Cognitive impairment, addiction, respiratory issues Schedule I
Cocaine 4,257 Second most used ATS after meth Heart attack, stroke, addiction Schedule II
Methamphetamine 2,384 Highly addictive stimulant Addiction, psychosis, organ damage Schedule II
Ecstasy 2,013 Popular among young people Heightened senses, lowered inhibitions, dangerous comedown Schedule I
Heroin 556 Highly addictive opiate Overdose, addiction, HIV/AIDS risk Schedule I

The Evolving Landscape of Marijuana Legality and Use

The increasing use of marijuana is closely tied to the shift towards state-level legalization in the U.S. As of late 2025, over half of U.S. states have legalized cannabis for medical or recreational use. This has increased accessibility and changed public perception, with many seeing it as less harmful than other illicit drugs. However, this perception can be misleading, as regular use still carries health risks, and product potency has increased significantly.

This changing legal and social landscape has significant public health implications. While legalization may bring benefits like regulated markets and tax revenue, it also raises concerns about potential increases in substance use disorders, impaired driving, and health issues from high-potency products.

Understanding the Effects and Risks of Marijuana

Marijuana use affects the mind and body. THC, the active compound, interacts with brain cells, impacting coordination, memory, and perception.

Short-term effects can include:

  • Altered senses and perception
  • Changes in mood
  • Increased appetite
  • Impaired memory and motor skills
  • Anxiety or paranoia
  • Increased heart rate

Long-term risks for heavy users include:

  1. Brain and Cognitive Impact: Regular use, especially in adolescence, is linked to lasting effects on memory, attention, and learning.
  2. Mental Health: Heavy use is associated with an increased risk of psychosis or schizophrenia in predisposed individuals and has been linked to depression and anxiety.
  3. Addiction: Approximately 3 in 10 cannabis users develop a use disorder, with higher risk for those starting before age 18.
  4. Respiratory Issues: Smoking cannabis exposes users to toxins, potentially leading to chronic bronchitis and inflammation.
  5. Cardiovascular Effects: Use can increase heart rate and blood pressure, potentially increasing the risk of heart problems.
  6. Cannabinoid Hyperemesis Syndrome (CHS): A rare condition in heavy users causing severe nausea and vomiting.

Conclusion: Navigating the Complexities of Marijuana Usage

Marijuana's status as the most used federally illegal drug highlights the conflict between federal law and public behavior. With millions of users globally and varied state laws in the U.S., the social and health implications are considerable. While perceptions of safety have changed with increased availability, the health risks of chronic use remain a serious concern. The ongoing debate over federal regulation aims to balance personal freedom with public health as cannabis use becomes more common. For further information, consult resources like the National Institute on Drug Abuse (NIDA) (https://nida.nih.gov/).

Note: Medical advice should be sought from a qualified healthcare professional. This content is for informational purposes only and does not constitute medical advice.

Frequently Asked Questions

Despite state-level changes, marijuana is classified as a Schedule I substance under the federal Controlled Substances Act. This classification indicates that the government believes it has a high potential for abuse and no accepted medical use.

While statistics fluctuate, recent data from Statista shows that cocaine is the second most used illegal drug in the United States, though its usage is far less widespread than marijuana.

Evidence from areas with new legalization suggests usage rates tend to increase. For example, Washington D.C. and Oregon experienced notable spikes in usage following legalization.

Long-term heavy use can lead to addiction (Cannabis Use Disorder), respiratory problems from smoking, and negative impacts on memory and cognitive function.

The risk of developing a use disorder for marijuana is lower than for highly addictive substances like opioids or cocaine. However, dependence and addiction to cannabis are still very real risks, particularly for those who start using it at a young age.

From a pharmacological perspective, the substance is the same, but the context and regulation differ. Recreational use is for personal enjoyment, while medical use involves a doctor's recommendation to treat specific health conditions.

In states where marijuana is still illegal, possession can result in penalties ranging from civil infractions and fines to misdemeanor or felony charges, depending on the amount and jurisdiction.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.